Pax genes during neural development and their potential role in neuroregeneration

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چکیده

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WITHDRAWN: Pax genes during neural development and their potential role in neuroregeneration.

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Pax genes have been cloned on the basis of their homology to the Drosophila segmentation gene paired. They share a common domain, the paired domain, that is sufficient to mediate sequence-specific DNA binding. Thus far, nine members have been characterized, which exhibit highly restricted temporal and spatial expression patterns. The analysis of mouse mutants has revealed their crucial role in ...

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Pax genes and their roles in cell differentiation and development.

Members of the Pax gene family are expressed in various tissues during ontogenesis. Evidence for their crucial role in morphogenesis, organogenesis, cell differentiation and oncogenesis is provided by rodent mutants and human diseases. Additionally, recent experimental in vivo and in vitro approaches have led to the identification of molecules that interact with Pax proteins.

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Pax genes in development.

The Pax gene family consists of nine members encoding nuclear transcription factors. Their temporally and spatially restricted expression pattern during embryogenesis suggests that they may play a key role during embryogenesis. Direct evidence for the important role of the Pax genes during embryonic development has been demonstrated by the correlation of mouse developmental mutants and human sy...

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PAX genes in development and disease: the role of PAX2 in urogenital tract development.

PAX genes play an important role in fetal development. Moreover, heterozygous mutations in several PAX genes cause human disease. Here we review the role of PAX2 in kidney development, focusing on the morphological effects of PAX2 mutations. We discuss the role of PAX2 in the context of an inhibitory field model of kidney branching morphogenesis and summarize recent progress in this area.

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ژورنال

عنوان ژورنال: Progress in Neurobiology

سال: 2011

ISSN: 0301-0082

DOI: 10.1016/j.pneurobio.2011.08.012